Mico-Shii - 70 capsules

Recommended daily dose: one or two capsules – or according to medical prescription – in the morning, preceded by one or two tablets of Askorbato K-HdT (rich in vitamin C) to promote the absorption of beta-glucans.

General precautions: Do not administer in case of allergy to mushrooms. In children under 6 years please use our infant preparations where the dose is adjusted according to bodyweight. Store in a cool and dry place. Do not use if the safety strip is damaged.

70 capsules of 620 mg. 100% vegetable capsules sealed with a natural antioxidant band.

Ingredients per capsule: 495 mg of Shiitake organic extract (Lentinula edodes); sealed vegetable capsule.

Each capsule is individually sealed with an antioxidant band that helps keep its contents in optimal conditions for longer.

The personalised color band for each product is designed to facilitate the differentiation of each extract when taking more than one. The ink of each band is of vegetable origin (carrot, pumpkin, apple, currant, etc.)

BIOACTIVE INGREDIENTS 
per 2 capsules

Polysaccharides 481 mg
- β-glucans 38.80 %
- α-glucans 27.90 %

Vitamins (natural source) 
- Vitamin B12 1.78 μg (71.20 % VRN*)
- Vitamin B2 0.02 mg (1.06 % VRN*)

Minerals 2 capsules (Natural source of minerals)
- Iron 0.134 mg (0.96% VRN*)
- Copper 0.006 mg (0.60% VRN*)

*NRV: nutrient reference values 

Allergens
Mico-Shii is suitable for celiacs, lactose intolerance, vegetarians and vegans. It is free of gluten, preservatives, chemicals, sweeteners, flavorings, starch, wheat, corn, soy, sugar and dairy. Non-GMO ingredients.

Metabolism:

Reduces levels of total cholesterol and increases HDL levels (1) therefore improving the lipid profile and reducing risk of cardiovascular diseases.

The immune system and tumours:

It has an immune modulating effect by activating macrophages and simulating the production of interleukins. Highly recommended for immunodeficient patients with cancer or other pathologies (2). Especially in gastric cancer where it has been shown to be able to prolong the patients survival in combination with chemotherapy (fluropyrimidine S - ) (3) , and in advanced colorectal cancer, where it can reduce the unwanted effects of chemotherapy (nausea and abdominal pain ) and improve immunological parameters (4).

The circulatory system:

Prevents high blood pressure (3). It reduces athermanous plaque, improves peripheral resistance and prevents thrombosis (4), all of which are modifiable cardivascular risk factors.

Liver:

Hepatic protection by improving liver function (5), effective in hepatitis B treatments.

Other actions:

Inhibits HIV enzymes (6), prevents cavities due to inhibition of dental plaque formation (7), during hyperuricemia treatments and prevents cachexia in cancer due to its alkalising action.

1. Fukushima M, Ohashi T, Fujiwara Y, Sonoyama K, Nakano M. Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, Shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats. Exp Biol Med (Maywood). 2001 Sep;226(8):758-65.

2. Xu X, Yan H, Zhang X. Structure and immuno-stimulating activities of a new heteropolysaccharide from Lentinula edodes. J Agric Food Chem. 2012 Nov 21; 60(46):11560-6. Epub 2012 Nov 12.

3. Ina K, Furuta R, Kataoka T, Kayukawa S, Yoshida T, Miwa T, Yamamura Y, Takeuchi Y. Lentinan prolonged survival in patients with gastric cancer receiving S-1-based chemotherapy. World J Clin Oncol. 2011  2(10):339-43.

4. Okuno K, Uno K. Efficacy of orally administered Lentinula edodes mycelia extract for advanced gastrointestinal cancer patients undergoing cancer chemotherapy: a pilot study. Asian Pac J Cancer Prev. 2011 12(7):1671-4.

5. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and Maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo). 1987 Oct;33(5):341-6.

6. Otsuka M, Shinozuka K, Hirata G, Kunitomo M. [Influences of a shiitake (Lentinus edodes)-fructo-oligosaccharide mixture (SK-204) on experimental pulmonary thrombosis in rats]. [Article in Japanese] Yakugaku Zasshi. 1996 Feb;116(2):169-73.

7. Yagi K. Liver protective effect of Lentinula edodes mycelia (LEM). Gan To Kagaku Ryoho. 2012 Jul;39(7):1099-102.

8. Sun J, Wang H, Ng TB. Isolation of a laccase with HIV-1 reverse transcriptase inhibitory activity from fresh fruiting bodies of the Lentinus edodes (Shiitake mushroom). Indian J Biochem Biophys. 2011 Apr;48(2):88-94.

9. Shouji N, Takada K, Fukushima K, Hirasawa M. Anticaries effect of a component from Shiitake (an edible mushroom). Caries Res. 2000 Jan-Feb;34(1):94-8.

10. Del Buono A et al. (2016) Polysaccharide from Lentinus edodes for integrative cancer treatment: immunomodulatory effects on lymphocyte population. World Cancer Research Journal 3, e652.

11. Gu J et al. (2015) Lentinan plays synergistic effects in paclitaxel-induced A549 cell apoptosis via activating ROS-TXNIP-NLRP3 signal. Journal of Cellular and Molecular Medicine 19, 1949-1955.

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For any specific conditions please contact us chris@masteryourgreatness.com

Should mushrooms be avoided in Autoimmune conditions? Are they immune stimulators?
Mushrooms are biological response modifiers (BRMs), or adaptogens, i.e. they modulate the immune system. So they modulate autoimmune conditions and inflammation levels in the body, whilst helping the body fight off pathogens. The most powerful immune modulator, recommended for autoimmune conditions, is Agaricus Blazei Murrill, or Sun mushroom (as in our MicoSol product), followed by reishi, then cordyceps sinensis is recommended for complaints like lupus.