Mico Sol - 70 Capsules

Recommended daily dose: one or two capsules – or according to medical prescription – in the morning, on a empty stomach 30mins before food.

General precautions:

Do not administer in case of allergy to mushrooms.In children under 6 years please use our infant preparations where the dose is adjusted according to bodyweight.Store in a cool and dry place. Do not use if the safety strip is damaged.

70 capsules of 745 mg. 100% vegetable capsules sealed with a natural antioxidant band.

Ingredients per capsule: 618 mg of organic extract of Agaricus blazei; vegetable capsule 127 mg; sealed vegetable capsule.

Each capsule is individually sealed with an antioxidant band that helps keep its contents in optimal conditions for longer.

The personalised color band for each product is designed to facilitate the differentiation of each extract when taking more than one. The ink of each band is of vegetable origin (carrot, pumpkin, apple, currant, etc.)

Bioactive ingredients (per 2 capsules)

β-glucans 29.00%
α-glucans 10.20%

Vitamins (per 2 capsules)

Vitamin B12 1.86 µg (74.40% VRN*)
Vitamin D 0.20 µg (4.16% VRN*)

Minerals (per 2 capsules)

Zinc 0.024 mg (0.24% VRN*)
Copper 0.014 mg (1.44% VRN*)

*NRV: nutrient reference values 

Allergens

Mico-Sol is suitable for celiacs, lactose intolerance, vegetarians and vegans. It is free of gluten, preservatives, chemicals, sweeteners, flavorings, starch, wheat, corn, soy, sugar and dairy. Non-GMO ingredients.

Immune system and anti-tumor potential:

Thanks to its immunomodulatory capacity, it becomes extremely useful in patients with cancer, as it has the potentila to improve the proliferation of T-lymphocytes and increase the activity of NK cells. It also increases phagpcytosis in macrophages and monocytes, and the proliferation of inflammatory cytokines IL -1b, IL-6 and interferon-y (1). It also has potential to reduce plasmatic levels if immunoglobulin E (igE), acting as an anti- allergy agent against reactions with intervention of IgE (2).

Anti - proliferative and anti-angiogenic capacity:

In tumour cells, A.blazei induces the stimulation of the apoptosis pathways that naturally regulate the programmed cell death (3,4). For the reason , it is considered an anti-proliferative agent on tumour cells and on the vascularization of these cells ensues (5).

In patients following chemotherapy, A. blazei helps to increase NK cells and appetite, showing improvements in alopecia, emotional stability and a decrease in overall weakness (6). A blazei has anti-angiogenic properties, by reducing tumour growth and angiogenesis (7).

Anti - allergy potential:

A. Blazei has an anti - allergy effect by means of macrophage activation and T-lymphocyte to Th1 cell differentiation, improving the balance of Th1/Th2 in mice (8,9).

Antifungal potential:

A. Blazei increases the fungicidal capacity against Candida albicans by increasing the production of peroxide hydrogen from macrophages (10).

Metabolism:

Improves tissue resistance to insulin by adapting glucose uptake in patients with type 11 diabetes (11). It also has a role in obesity orevention (12).

Liver:

Reduces transaminase levels by improving liver function in patients with chronic hepatitis (13). In addition, A. Blazei possesses adjuvent capacity in th eimmunization produced by DNA vaccine of the hepatitis B virus, inducing an increase in the T cells and synthesis of specific antibodies (14).

1. Jiang L, Yu Z, Lin Y, Cui L, Yao S, Lv L, Liu J. Low-molecular-weight polysaccharides from Agaricus blazei Murrill modulate the Th1 response in cancer immunity. Oncol Lett. 2018 Mar;15(3):3429-3436. doi: 10.3892/ol.2018.7794.

2. Tangen JM, Holien T, Mirlashari MR, Misund K, Hetland G. Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by the Agaricus blazei Murill Based Mushroom Extract, Andosan™. Biomed Res Int. 2017; 2017:2059825. doi: 10.1155/2017/2059825

3. Martins PR, de Campos Soares ÂMV, da Silva Pinto Domeneghini AV, Golim MA, Kaneno R. Agaricus brasiliensis polysaccharides stimulate human monocytes to capture Candida albicans, express toll-like receptors 2 and 4, and produce pro-inflammatory cytokines. J Venom Anim Toxins Incl Trop Dis. 2017 Mar 23;23:17. doi: 10.1186/s40409-017-0102-2

4. Hetland G, Eide DM, Tangen JM, Haugen MH, Mirlashari MR, Paulsen JE. The Agaricus blazei-Based Mushroom Extract, Andosan™, Protects against Intestinal Tumorigenesis in the A/J Min/+ Mouse. PLoS One. 2016 Dec 21;11(12):e0167754. doi: 10.1371/journal.pone.0167754.

5. Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. Cytokine Levels After Consumption of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™ , in Patients with Crohn’s Disease and Ulcerative Colitis in a Randomized Single-Blinded Placebo-Controlled Study. Scand J Immunol. 2016 Dec;84(6):323-331. doi: 10.1111/sji.12476.

6. Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. Effect of the Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSanTM, on Symptoms, Fatigue and Quality of Life in Patients with Crohn’s Disease in a Randomized Single-Blinded Placebo Controlled Study. PLoS One. 2016 Jul 14;11(7):e0159288. doi: 10.1371/journal.pone.0159288.

7. Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, on Symptoms, Fatigue and Quality of Life in Patients with Ulcerative Colitis in a Randomized Single-Blinded Placebo Controlled Study. PLoS One. 2016 Mar 2;11(3):e0150191. doi: 10.1371/journal.pone.0150191.

8. Singh R, Dhingra GS, Shri R. Evaluation of Antianxiety Potential of Four Ganoderma (Agaricomycetes) Species from India in Mice. Int J Med Mushrooms. 2016;18(11):991-998. doi: 10.1615

9. Jiang WG, Sanders AJ, Katoh M, Ungefroren H, Gieseler F, Prince M, Thompson SK, Zollo M, Spano D, Dhawan P, Sliva D, Subbarayan PR, Sarkar M, Honoki K, Fujii H, Georgakilas AG, Amedei A, Niccolai E, Amin A, Ashraf SS, Ye L, Helferich WG, Yang X, Boosani CS, Guha G, Ciriolo MR, Aquilano K, Chen S, Azmi AS, Keith WN, Bilsland A, Bhakta D, Halicka D, Nowsheen S, Pantano F, Santini D. Tissue invasion and metastasis: Molecular, biological and clinical perspectives. Semin Cancer Biol. 2015 Dec;35 Suppl:S244-S275. doi: 10.1016/j.semcancer.2015.03.008.

10. Liu Y, Zhang L, Zhu X, Wang Y, Liu W, Gong W. Polysaccharide Agaricus blazei Murill stimulates myeloid derived suppressor cell differentiation from M2 to M1 type, which mediates inhibition of tumour immune-evasion via the Toll-like receptor 2 pathway. Immunology. 2015 Nov;146(3):379-91. doi: 10.1111/imm.12508.

11. Val CH, Brant F, Miranda AS, Rodrigues FG, Oliveira BC, Santos EA, Assis DR, Esper L, Silva BC, Rachid MA, Tanowitz HB, Teixeira AL, Teixeira MM, Régis WC, Machado FS. Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria. Malar J. 2015 Aug 11;14:311. doi: 10.1186/s12936-015-0832-y

12. Yeh MY, Shang HS, Lu HF, Chou J, Yeh C, Chang JB, Hung HF, Kuo WL, Wu LY, Chung JG. Chitosan oligosaccharides in combination with Agaricus blazei Murill extract reduces hepatoma formation in mice with severe combined immunodeficiency. Mol Med Rep. 2015 Jul;12(1):133-40. doi: 10.3892/mmr.2015.3454.

13. de Jesus Pereira NC, Régis WC, Costa LE, de Oliveira JS, da Silva AG, Martins VT, Duarte MC, de Souza JR, Lage PS, Schneider MS, Melo MN, Soto M, Soares SA, Tavares CA, Chávez-Fumagalli MA, Coelho EA. Evaluation of adjuvant activity of fractions derived from Agaricus blazei, when in association with the recombinant LiHyp1 protein, to protect against visceral leishmaniasis. Exp Parasitol. 2015 Jun;153:180-90. doi: 10.1016/j.exppara.2015.03.027.

14. Tangen JM, Tierens A, Caers J, Binsfeld M, Olstad OK, Trøseid AM, Wang J, Tjønnfjord GE, Hetland G. Immunomodulatory effects of the Agaricus blazei Murrill-based mushroom extract AndoSan in patients with multiple myeloma undergoing high dose chemotherapy and autologous stem cell transplantation: a randomized, double blinded clinical study. Biomed Res Int. 2015;2015:718539. doi: 10.1155/2015/718539.

15. Socala K, Nieoczym D, Grzywnowicz K, Stefaniuk D, Wlaz P. Evaluation of Anticonvulsant, Antidepressant-, and Anxiolytic-like Effects of an Aqueous Extract from Cultured Mycelia of the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes) in Mice. Int J Med Mushrooms. 2015;17(3):209-18.

16. de Sá-Nakanishi AB, Soares AA, Natali MR, Comar JF, Peralta RM, Bracht A. Effects of the continuous administration of an Agaricus blazei extract to rats on oxidative parameters of the brain and liver during aging. Molecules. 2014 Nov 13;19(11):18590-603. doi: 10.3390/molecules191118590.

17. Wang H, Li G, Zhang W, Han C, Xu X, Li YP. The protective effect of Agaricus blazei Murrill, submerged culture using the optimized medium composition, on alcohol-induced liver injury. Biomed Res Int. 2014;2014:573978. doi: 10.1155/2014/573978.

18. Matsuzaki H, Shimizu Y, Iwata N, Kamiuchi S, Suzuki F, Iizuka H, Hibino Y, Okazaki M. Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats. BMC Complement Altern Med. 2013 Dec 26;13:370. doi: 10.1186/1472-6882-13-370.

19. Wang P, Li XT, Sun L, Shen L. Anti-Inflammatory Activity of Water-Soluble Polysaccharide of Agaricus blazei Murill on Ovariectomized Osteopenic Rats. Evid Based Complement Alternat Med. 2013;2013:164817. doi: 10.1155/2013/164817.

20. Cui L, Sun Y, Xu H, Xu H, Cong H, Liu J. A polysaccharide isolated from Agaricus blazei Murill (ABP-AW1) as a potential Th1 immunity-stimulating adjuvant. Oncol Lett. 2013 Oct;6(4):1039-1044.

21. Hakime-Silva RA, Vellosa JC, Khalil NM, Khalil OA, Brunetti IL, Oliveira OM. Chemical, enzymatic and cellular antioxidant activity studies of Agaricus blazei Murrill. An Acad Bras Cienc. 2013 Sep;85(3):1073-81. doi: 10.1590/S0001-37652013005000044.

22. Lima CU, Souza VC, Morita MC, Chiarello MD, Karnikowski MG. Agaricus blazei Murrill and inflammatory mediators in elderly women: a randomized clinical trial. Scand J Immunol. 2012 Mar;75(3):336-41. doi: 10.1111/j.1365-3083.2011.02656.x.

23 .Hsu CH, Hwang KC, Chiang YH, Chou P. The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B. J Altern Complement Med. 2008 Apr;14(3):299-301. doi: 10.1089/acm.2006.6344.

24. Kimura N, Fujino E, Urabe S, Mizutani H, Sako T, Imai S, Toyoda Y, Arai T. Effect of supplementation of Agaricus mushroom meal extracts on enzyme activities in peripheral leukocytes of calves. Res Vet Sci. 2007 Feb;82(1):7-10.

25. Hsu CH, Liao YL, Lin SC, Hwang KC, Chou P. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med. 2007 Jan-Feb;13(1):97-102.

26. Grinde B, Hetland G, Johnson E. Effects on gene expression and viral load of a medicinal extract from Agaricus blazei in patients with chronic hepatitis C infection. Int Immunopharmacol. 2006 Aug;6(8):1311-4.

27. Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP. Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Int J Gynecol Cancer. 2004 Jul-Aug;14(4):589-94.

Shipping
Shipping is free on orders over £100. Place your order today and you will receive it in 24-72 hours.

Payment Methods
You can make a secure payment by credit card and Paypal.

For any specific conditions please contact us chris@masteryourgreatness.com

Should mushrooms be avoided in Autoimmune conditions? Are they immune stimulators?
Mushrooms are biological response modifiers (BRMs), or adaptogens, i.e. they modulate the immune system. So they modulate autoimmune conditions and inflammation levels in the body, whilst helping the body fight off pathogens. The most powerful immune modulator, recommended for autoimmune conditions, is Agaricus Blazei Murrill, or Sun mushroom (as in our MicoSol product), followed by reishi, then cordyceps sinensis is recommended for complaints like lupus.